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Sketches include: A Message From the Vice-President of the United States, Lance Armstrong Monologue, Celebrity Iron Man, Totally Rad Smoke Detector 3000, The Indigo Girls (with Sheryl Crow cameo), The O'Reilly Factor, Weekend Update with guests Finesse Mitchell, Scott Podsednik, and Mrs Butterworth, A Song for Sheryl (with Sheryl Crow cameo), Days of Our Lives, Carol!, Hit Man. Sheryl Crow performs "Good Is Good" and "Strong Enough". Maya Rudolph is absent for maternity leave.