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When a patient named Margaret McPherson is admitted to Princeton Plainsboro after suffering severe and uncontrollable vomiting, House and the team make unexpected discoveries about her identity as they assess her symptoms. When the symptoms don't improve, the team looks to the patient's medical history to unearth more about her past. Meanwhile, House gives Chase's new hire a cold welcome, and a visit from House's massage therapist forces House and Cuddy to confront the reservations in their relationship.